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Bacterial virulence and infectious disease
Présentation générale
- Nom de l'unité de recherche : Bacterial virulence and infectious disease
- Tutelle : INSERM et UM1
- Type et numéro : U1047 (ex ESPRI26 et EA 4204)
- Titre, prénom et nom du directeur : David O'Callaghan
- Domaine de recherche :
- Biologie, santé, chimie, sciences de la Terre
- Personnel statutaire et non statutaire : 16
- Description des équipes de recherche :
Recherche
- Thématiques:
Brucella, Burkholderia, Pied diabetique, Virulence bactérienne, Systèmes de sécrétion type IV
- Expertises, compétences et savoir faire:
Genétique bactérienne, modèles d'infection (cellules, nematodes, poisson zebre), biologie cellulaire.
Rayonnement
- Dernières publications majeures:
2010
- O'Callaghan D, Vergunst A (2010) Non-mammalian animal models to study infectious disease: worms or fly fishing? Curr Opinion Microbiol 13 : 79-85
- Vergunst AC, Meijer AH, Renshaw SA, O'Callaghan D (2010) Burkholderia cenocepacia creates an intra-macrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection. Infect Immun. 78: 1495-1508
2009
- Amalric J, Mutin PH, Guerrero G, Ponche A, Sotto A, Lavigne PH (2009) Phosphonate monolayers functionalized by silver thiolate species as antibacterial nanocoating on titanium and stainless steel. J. Mater Chem. 19: 141-149
- Bourg G, Sube R, O'Callaghan D Patey G (2009). Interactions between Brucella suis VirB8 and its homolog TraJ from the plasmid pSB102 underline the dynamic nature of type IV secretion systems. J Bacteriol 191, 2985-2992
- Martin FA, Posadas DM, Carrica MC, Cravero SL, O'Callaghan D, Zorreguieta A (2009) Interplay between two RND systems mediating antimicrobial resistance in Brucella suis . J Bacteriol 191, 2530-2540.
2008
- Alix E, Blanc-Potard AB (2008) Peptide-assisted degradation of the Salmonella MgtC virulence factor. EMBO J 27, 546-557.
- Lavigne JP, Bourg G, Combescure C, Botto H, Sotto A (2008) In vitro and in vivo evidences of dose-dependent decrease of uropathogen Escherichia coli virulence after consumption of Vaccinium macrocarpon cranberry (Urell®). Clin Microbiol Inf 14(4):350-5.
- Lavigne JP, Nicolas-Chanoine MH, Bourg G, Moreau J, Sotto A (2008) Virulent synergistic effect between Enterococcus faecalis and Escherichia coli assayed by using the Caenorhabditis elegans model. PLoS One 3(10):e3370.
- Nicolas-Chanoine MH, Blanco J, Leflon-Guibout V, Demarty R, Alonso MP, Caniça MM, Park YJ, Lavigne JP, Pitout J, Johnson JR (2008) Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15. J Antimicrob Chemother 61(2): 273-281.
- Richard JL, Sotto A, Jourdan N, Combescure C, Vannereau D, Rodier M, Lavigne JP (2008) Risk factors for and impact on healing of multidrug-resistant bacteria in diabetic foot ulcers. Diabetes Metab 34: 363-369.
- Sotto A, lina G, Richard JL, Combescure C, Bourg G, Vidal L, Jourdan N, Etienne J, Lavigne JP (2008) Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. Diabetes Care 31: 2318-24
- Yumuk Z, Afacan G, Nicolas-Chanoine MH, Sotto A, Lavigne JP (2008) Turkey: a further country concerned by community-acquired Escherichia coli clone O25-ST131 producing CTX-M-15. J Antimicrob Chemother 62(2):284-8.
- Projets et appels d'offres en cours:
ANR MIE
2 Chercheuses/eurs d'avenir de region LR
Partenariats et collaborations
- Partenariats et entreprises de référence:
Proteus SA, Nimes. ApoH, Montpellier
Rattachement
- UFR de rattachement:
International
- Programmes européens et internationaux: ERA Net RNAi Net. Coordinateur T Meyer, Max Planck Institute, Berlin
Nous contacter
INSERM U1047
UFR Médecine Site de Nimes
186, chemin du Carreau de Lanes
CS 83021
30908 NIMES Cedex 2
France
Tel : +33 466 02 81 46
FAX +33 466 02 81 48
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